The 49ers have once again been hit by the injury bug following Sunday’s win over the Seahawks: 🔶QB Brock Purdy (left shoulder/toe): Uncertain for Week 2 🔶TE George Kittle (hamstring): Out 3-5 weeks 🔶WR Jauan Jennings (shoulder): Awaiting CT scan The 49ers play the Saints next.

You’ve laid it all out: after their Sunday matchup with the Seahawks, the 49ers are indeed grappling with a troubling wave of injuries. Let’s dive into the latest:

Quarterback Brock Purdy played through a sprained left (non-throwing) shoulder and a toe injury. Head coach Kyle Shanahan emphasized that the toe is the more serious concern, and Purdy’s availability for Week 2 against the Saints is uncertain. If he can’t go, veteran Mac Jones is poised to start

Tight end George Kittle left the game early with a hamstring injury, following a strong opener that included four catches for 25 yards and a touchdown. He’s now expected to miss “a few weeks,” with projections ranging from three to five, and there’s even talk of placing him on injured reserve—which would mandate at least a four‑game absence

Wide receiver Jauan Jennings suffered a shoulder injury late in the game. An MRI came back clean, but he’ll undergo a CT scan for further evaluation

In response to these roster setbacks, the team moved quickly, re-signing Kendrick Bourne on a one‑year deal (up to $5 million). Bourne, who began his career in San Francisco before spending four seasons with New England, is expected to provide immediate receiving depth \

Here’s how the situation breaks down:

  • Purdy: dual injuries (shoulder + toe); toe is more worrisome; status for Week 2 unknown; Mac Jones in line to start if needed.
  • Kittle: hamstring injury; likely sidelined for 3–5 weeks; IR a possibility.
  • Jennings: shoulder injury; better news on MRI, but CT scan pending.
  • Bourne: signed as a depth addition in wake of wide receiver injuries.

The Saints game looms large. If Purdy is out, Mac Jones—a capable backup who started for both the Patriots and Jaguars—will task to lead the offense. The absence of Kittle—arguably the team’s most reliable receiving target in the red zone—will force significant adjustments. Jennings’ uncertain status tightens the receiving corps too. Bourne’s return offers a glimmer of help, but it remains to be seen how quickly he can sync with this offense.

Without Kittle, pressure will fall on backups like Luke Farrell and Jake Tonges, the latter having already caught the game‑winner on Sunday The team’s offensive flow and play‑calling must adapt fast, and there’ll likely be a greater emphasis on the running game and short passes.

Missing Purdy would shift the entire offensive dynamic. Mac Jones brings a different style—less mobility, a more traditional drop‑back approach. Shanahan’s offense will need to simplify in spots, at least until regulars begin to return.

Looking ahead, how the Niners navigate this short‑term adversity may define the early stretch of their season. If Purdy and Kittle return within the projected windows, it could temper the impact. But in the meantime, resilience—especially from supporting players and depth pieces like Bourne and Tonges—will be key.

Let me know if you’d like a breakdown of how Mac Jones fits the offense, a look at Saints’ defense to predict matchups, or explore potential waiver-wire options for fantasy purposes.

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